Things happen; you just have to accept it.
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That is just the way things happen, and there is nothing you can do about it.
When you say that's the way the cookie crumbles, you are accepting an unfortunate outcome as part of life.
It is used to express acceptance of a disappointment with a philosophical, slightly resigned attitude.
"That's Life"
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A general acceptance that difficult things happen as part of living
"Such Is Life"
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An expression of resigned acceptance toward an unfortunate situation
"That's the Way the Cookie Crumbles"
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Accepting a specific bad outcome with a shrug — that is just how it turned out