To start something that releases many new problems.
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To start something that releases many new problems you cannot control.
When you open Pandora's box, one action or one question sets off a series of difficulties that nobody can put back.
It comes from a Greek myth and suggests the damage is lasting.
"Open a Can of Worms"
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Create messy complications, usually recoverable
"The Thin End of the Wedge"
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A small start that leads somewhere worse
"Open Pandora's Box"
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Release many problems you can't take back