A factor that leads to the end or failure of something.
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The final blow that ends something already going downhill.
A nail in the coffin is the thing that finishes off a plan, a job, or a good name.
It is used to mark the clear, final end of something.
"The Last Straw"
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The final, often small, problem that causes someone to finally lose patience after a series of issues
"Seal Someone's Fate"
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Making an outcome certain and permanent, usually a negative one
"A Nail in the Coffin"
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The final decisive action that ends something already failing or dying