To be clumsy or awkward in handling things.
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To be very awkward with your hands.
When someone is all thumbs, they drop things, make mistakes with simple tasks, or struggle with anything that needs care.
It is often used in a light-hearted way about someone who is naturally awkward with their hands.
"Butter Fingers"
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Dropping things specifically due to not gripping them well
"Left-footed"
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Feeling awkward around people, not awkward with your hands
"To Be All Thumbs"
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Being generally awkward and uncoordinated with your hands