To be very surprised and scared by something you did not expect.
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To be so startled that your whole body jolts.
Jumping out of your skin describes a sharp fright.
Your heart leaps and your body reacts before your mind catches up.
"Jump a Mile"
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Very similar — also means being sharply startled; jump out of your skin implies a stronger physical reaction
"Have a Heart Attack"
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Used hyperbolically for shock — jump out of your skin focuses on the startle reflex specifically
"Jump out of Your Skin"
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Being so suddenly surprised that your body reacts with an involuntary jolt of shock