To become very angry very quickly; suddenly lose one's temper.
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To suddenly become very angry and lose control of your temper.
When someone flies off the handle, they react with rage that seems out of proportion to the situation.
It's used when someone has an unexpectedly explosive reaction to something.
"Lose Your Cool"
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To stop being calm and become visibly upset or agitated
"Blow Up"
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To suddenly explode in anger, often loudly and with consequences
"Fly off the Handle"
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Suddenly losing control of your temper in a disproportionate, explosive way