So worried and desperate about something that you don't know what to do next.
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Completely frustrated and out of ideas on how to solve a problem.
When you're at your wit's end, you've tried everything you can think of and nothing has worked.
It expresses deep exhaustion and desperation, not just mild annoyance.
"Fed Up"
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Thoroughly annoyed and out of patience, without the helpless exhaustion
"At a Loss"
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Confused about what to think or do, not necessarily frustrated or desperate
"At Your Wit's End"
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Completely out of ideas and at the very limit of your patience and ability