Two incomparable things.
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Two things so different that you cannot fairly compare them.
When you say something is apples and oranges, the two are simply not the same kind of thing.
It is used to push back on a comparison that does not hold up.
"Chalk and Cheese"
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Two people or things that are completely different from each other in character
"A Different Kettle of Fish"
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A situation that is completely separate and different from what was being discussed
"Apples and Oranges"
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Two things too different from each other to be fairly compared