Two incomparable things.
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Two things that are so different they cannot be meaningfully compared.
When you say something is apples and oranges, you are pointing out that the comparison being made is unfair because the two things are fundamentally different.
It is used to push back on comparisons that do not hold up logically.
"Chalk and Cheese"
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Two people or things that are completely different from each other in character
"A Different Kettle of Fish"
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A situation that is completely separate and different from what was being discussed
"Apples and Oranges"
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Two things too different from each other to be fairly compared